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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2A
All Species:
33.64
Human Site:
S103
Identified Species:
52.86
UniProt:
P11388
Number Species:
14
Phosphosite Substitution
Charge Score:
0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P11388
NP_001058.2
1531
174385
S103
K
Q
R
D
P
K
M
S
C
I
R
V
T
I
D
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
T132
K
Q
R
D
K
N
M
T
C
I
K
V
S
I
D
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
T118
K
Q
R
D
K
N
M
T
C
I
K
V
S
I
D
Dog
Lupus familis
XP_537646
1532
174610
S103
K
Q
R
D
P
K
M
S
C
I
R
V
T
I
D
Cat
Felis silvestris
Mouse
Mus musculus
Q01320
1528
172859
S102
K
Q
R
D
P
K
M
S
C
I
R
V
T
I
D
Rat
Rattus norvegicus
P41516
1526
173202
S102
K
Q
R
D
P
K
M
S
C
I
R
V
T
M
M
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519680
1746
195650
S131
K
Q
R
D
N
K
M
S
C
I
K
V
T
I
D
Chicken
Gallus gallus
O42130
1553
174974
S104
K
Q
R
D
K
S
M
S
C
I
K
V
T
I
D
Frog
Xenopus laevis
NP_001082502
1579
178601
S101
K
Q
R
D
P
T
M
S
C
I
K
I
T
I
D
Zebra Danio
Brachydanio rerio
NP_001003834
1574
177254
N102
K
Q
R
D
K
T
M
N
C
I
K
V
N
I
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
I88
K
S
M
N
T
I
K
I
D
I
D
P
E
R
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
N138
K
Q
R
D
P
K
M
N
T
I
K
I
T
I
N
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
N128
K
Q
R
D
P
T
M
N
C
I
K
I
T
L
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
D103
K
Q
R
D
A
K
M
D
S
V
Q
V
V
I
D
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
H89
K
R
I
D
V
N
I
H
A
E
E
H
T
I
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
67.2
67.5
93.6
N.A.
89
88.7
N.A.
71.3
76.3
70.7
67.9
N.A.
51.2
N.A.
53
58.9
Protein Similarity:
100
78.6
78.4
96.4
N.A.
93.6
93.2
N.A.
79.1
85
81.8
78.8
N.A.
66.8
N.A.
70.4
73.4
P-Site Identity:
100
66.6
66.6
100
N.A.
100
86.6
N.A.
86.6
80
80
66.6
N.A.
13.3
N.A.
66.6
66.6
P-Site Similarity:
100
86.6
86.6
100
N.A.
100
93.3
N.A.
93.3
86.6
93.3
80
N.A.
26.6
N.A.
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
45
42.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
61.4
60.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
7
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
74
0
0
0
0
0
0
% C
% Asp:
0
0
0
94
0
0
0
7
7
0
7
0
0
0
74
% D
% Glu:
0
0
0
0
0
0
0
0
0
7
7
0
7
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
7
0
0
0
% H
% Ile:
0
0
7
0
0
7
7
7
0
87
0
20
0
80
0
% I
% Lys:
100
0
0
0
27
47
7
0
0
0
54
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% L
% Met:
0
0
7
0
0
0
87
0
0
0
0
0
0
7
7
% M
% Asn:
0
0
0
7
7
20
0
20
0
0
0
0
7
0
14
% N
% Pro:
0
0
0
0
47
0
0
0
0
0
0
7
0
0
0
% P
% Gln:
0
87
0
0
0
0
0
0
0
0
7
0
0
0
0
% Q
% Arg:
0
7
87
0
0
0
0
0
0
0
27
0
0
7
0
% R
% Ser:
0
7
0
0
0
7
0
47
7
0
0
0
14
0
0
% S
% Thr:
0
0
0
0
7
20
0
14
7
0
0
0
67
0
0
% T
% Val:
0
0
0
0
7
0
0
0
0
7
0
67
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _